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In their study, human-derived monocytes were treated with either PMA, pharmacologic G6PD inhibitor 6-AN, G6PD-silencing siRNA, siRNA + hyperglycemia, or hyperglycemia alone and then inspected for changes in monocyte polarization without an immunogenic stimulus

Dysregulation of metabolic homeostasis underpins many major and socially burdensome human diseases including cancer, Type 2 diabetes, fatty liver disease and obesity [2]

Deletion of TXNIP mitigates high-fat diet-impaired angiogenesis and prevents inflammation in a mouse model of critical limb ischemia

Future efforts integrating stimuli-responsive materials and multimodal payloads promise even greater specificity and efficacy in MS treatment

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Upon oxidation, it forms a disulfide-bonded dimer (GSSG)